Am sure Simpsons is listed but..there have been giant-tiny
moments on The Simpsons including the "couch gags" at
the start. Here is a closeup from one that had Bart and Lisa
as adult sized and their parents as kid sized--with Maggie as
a doll being held by Homer.Imagine if Bart were still a kid
but 6 feet tall, and his dad only 3 or 4 feet tall (here Homer
looks like an unhappy kid).
Another opening had the family's sizes reversed--Homer the smallest, Maggie the biggest, though Bart seemed the same
size as usual.
Another opening had the family shrinking to a few inches tall
and fleeing to a mouse hole and various show plots, comic book covers, and fan art have shown them at different
sizes including giant.
Season 10 Maximum Homerdrive
"Marge and Homer are depicted as children while Bart and Lisa are depicted as adults (and Maggie is a baby doll in Homer’s arms). Homer reaches for the remote control, but Lisa slaps it away from him."
I have still pic that I cropped at top but too big to put
on the forum.May try to convert from .png to .jpg